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Anticancer Res. 2015 Oct;35(10):5655-60.

Diagnostic Accuracy of Tumor Markers CYFRA21-1 and CA125 in the Differential Diagnosis of Ascites.

Author information

1
Department of Laboratory Medicine, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain jtrape@althaia.cat.
2
Polytechnic School University of Vic-Central University of Catalonia, Vic, Catalonia, Spain.
3
Department of Laboratory Medicine, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
4
Department of Medical Oncology, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain Clinical Research Unit, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
5
Clinical Research Unit, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
6
Department of Pathology, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
7
Department of Medical Oncology, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
8
Department of Internal Medicine, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
9
Department of Gynecology and Obstetrics, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
10
Department of Gastroenterology, Althai Healthcare University Network of Manresa, Manresa, Catalonia, Spain.
11
Clinical Chemistry Hospital Clinic Barcelona, Barcelona, Spain.

Abstract

BACKGROUND:

The usefulness of tumor markers in the differential diagnosis of cancer in patients with ascites remains a matter of controversy. Few studies have reported the measurement of cancer antigen 125 (CA125) and cytokeratin 19 soluble fragments (CYFRA21-1) in ascitic fluid. The aim of the present study was to evaluate the diagnostic accuracy of these tumor markers in the detection of malignant ascites.

MATERIALS AND METHODS:

We analyzed CA125 and CYFRA21-1 from 143 consecutive undiagnosed patients with ascitis.

RESULTS:

Use of CA125 gave a sensitivity of 39.7% and a specificity of 98.8%, and CYFRA21-1 a sensitivity of 50.0% and a specificity of 97.6% in differential diagnosis of malignant ascites. For combined use of CA125 plus CYFRA21-1, sensitivity was 65.5% and specificity 96.5%. In patients with negative cytology, these two tumor markers had a sensitivity of 50% and a specificity of 96.5%.

CONCLUSION:

The determination of tumor markers in ascitic fluid could be useful for the diagnostic assessment of patients with ascites.

KEYWORDS:

Ascitic fluid; CA125; CYFRA 21-1; differential diagnosis; malignant effusion

PMID:
26408739
[Indexed for MEDLINE]

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