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Anticancer Res. 2015 Oct;35(10):5491-7.

Effect of Increased Radiotoxicity on Survival of Patients with Non-small Cell Lung Cancer Treated with Curatively Intended Radiotherapy.

Author information

1
Center for Research and Development, Uppsala University, Gävle Hospital, Gävle, Sweden Department of Oncology, Gävle Hospital, Gävle, Sweden Holgersson@regiongavleborg.se.
2
Center for Research and Development, Uppsala University, Gävle Hospital, Gävle, Sweden Department of Oncology, Gävle Hospital, Gävle, Sweden.
3
Center for Research and Development, Uppsala University, Gävle Hospital, Gävle, Sweden.
4
Department of Oncology, Gävle Hospital, Gävle, Sweden.
5
Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden.
6
Department of Oncology, Karolinska University Hospital, Stockholm, Sweden.
7
Department of Oncology, Uppsala University Hospital, Uppsala, Sweden.
8
Department of Radiation Sciences and Oncology, Umeå University Hospital, Umeå, Sweden.
9
Center for Research and Development, Uppsala University, Gävle Hospital, Gävle, Sweden Department of Oncology, Gävle Hospital, Gävle, Sweden Department of Radiation Sciences and Oncology, Umeå University Hospital, Umeå, Sweden.

Abstract

AIM:

To elucidate the impact of different forms of radiation toxicities (esophagitis, radiation pneumonitis, mucositis and hoarseness), on the survival of patients treated with curatively intended radiotherapy for non-small cell lung cancer (NSCLC).

PATIENTS AND METHODS:

Data were individually collected retrospectively for all patients diagnosed with NSCLC subjected to curatively intended radiotherapy (≥50 Gy) in Sweden during the time period 1990 to 2000.

RESULTS:

Esophagitis was the only radiation-induced toxicity with an impact on survival (hazard ratio=0.83, p=0.016). However, in a multivariate model, with clinical- and treatment-related factors taken into consideration, the impact of esophagitis on survival was no longer statistically significant (hazard ratio=0.88, p=0.17).

CONCLUSION:

The effect on survival seen in univariate analysis may be related to higher radiation dose and to the higher prevalence of chemotherapy in this group. The results do not suggest that the toxicities examined have any detrimental effect on overall survival.

KEYWORDS:

NSCLC; esophagitis; radiotherapy; survival; toxicity

PMID:
26408714
[Indexed for MEDLINE]

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