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Handb Exp Pharmacol. 2015;231:341-65. doi: 10.1007/978-3-319-20825-1_12.

Endocannabinoids and Reproductive Events in Health and Disease.

Author information

1
Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
2
European Center for Brain Research/IRCCS Santa Lucia Foundation, Rome, Italy.
3
Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Rome, Italy.
4
European Center for Brain Research/IRCCS Santa Lucia Foundation, Rome, Italy. m.maccarrone@unicampus.it.
5
School of Medicine and Center of Integrated Research, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, 00128, Rome, Italy. m.maccarrone@unicampus.it.

Abstract

The lasting research on the endocannabinoid system (ECS) has now provided solid and convincing evidence that proves the detrimental effects of recreational drug abuse (a growing habit among teenagers) on fertility. Endocannabinoids (eCBs) affect reproductive events from gametogenesis to fertilization, from embryo implantation to the final outcome of pregnancy and, thus, they have been proposed as suitable biomarkers to predict the reproductive potential of male and female gametes in clinical practice. Novel tools for reproductive medicine are highly sought after, and here we report the latest findings on the impact of the ECS on fertility, demonstrating how basic research can be translated into new medical strategies.

KEYWORDS:

AEA Anandamide; Biomarkers; Endocannabinoid system; Infertility; Reproduction

PMID:
26408167
DOI:
10.1007/978-3-319-20825-1_12
[Indexed for MEDLINE]

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