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Handb Exp Pharmacol. 2015;231:317-39. doi: 10.1007/978-3-319-20825-1_11.

Endocannabinoids and the Endocrine System in Health and Disease.

Author information

1
Neuroscience Research Center and Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA. chillard@mcw.edu.

Abstract

Some of the earliest reports of the effects of cannabis consumption on humans were related to endocrine system changes. In this review, the effects of cannabinoids and the role of the CB1 cannabinoid receptor in the regulation of the following endocrine systems are discussed: the hypothalamic-pituitary-gonadal axis, prolactin and oxytocin, thyroid hormone and growth hormone, and the hypothalamic-pituitary-adrenal axis. Preclinical and human study results are presented.

KEYWORDS:

Corticosterone; Gonadotropin; Gonadotropin-releasing hormone; Growth hormone; HPA axis; Oxytocin; Prolactin; Testosterone; Thyroid hormone

PMID:
26408166
PMCID:
PMC6813821
DOI:
10.1007/978-3-319-20825-1_11
[Indexed for MEDLINE]
Free PMC Article

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