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PLoS One. 2015 Sep 25;10(9):e0139018. doi: 10.1371/journal.pone.0139018. eCollection 2015.

Intrinsic Affective Network Is Impaired in Children with Attention-Deficit/Hyperactivity Disorder.

Author information

1
Center for Cognitive Neuroscience, Neuroscience & Behavioral Disorders Program, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore; Research Division, Institute of Mental Health, Singapore, Singapore.
2
Center for Cognitive Neuroscience, Neuroscience & Behavioral Disorders Program, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore.
3
Center for Cognitive Neuroscience, Neuroscience & Behavioral Disorders Program, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore; Department of Child and Adolescent Psychiatry, Institute of Mental Health, Singapore, Singapore.
4
Department of Child and Adolescent Psychiatry, Institute of Mental Health, Singapore, Singapore.
5
Center for Cognitive Neuroscience, Neuroscience & Behavioral Disorders Program, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore; Clinical Imaging Research Centre, The Agency for Science, Technology and Research-National University of Singapore, Singapore, Singapore.

Abstract

Deficits in impulsivity and affect dysregulation are key features of attention-deficit/hyperactivity disorder (ADHD) besides impairing levels of hyperactivity and/or inattention. However, the neural substrates underlying these traits are relatively under-investigated. In this study, we use resting-state functional magnetic resonance imaging to test the hypothesis of diminished functional integration within the affective/limbic network (which includes the amygdala, hippocampus, subgenual cingulate cortex, orbitofrontal cortex and nucleus accumbens) of children with ADHD, which is associated with their behavioral measures of emotional control deficits. Resting state-fMRI data were obtained from 12 healthy control subjects and 15 children with ADHD, all who had a minimum one-month washout period for medications and supplements. Children with ADHD demonstrated less integrated affective network, evidenced by increased bilateral amygdalar and decreased left orbitofrontal connectivity within the affective network compared to healthy controls. The hyper-connectivity at the left amygdalar within the affective network was associated with increased aggressiveness and conduct problems, as well as decline in functioning in children with ADHD. Similar findings in affective network dysconnectivity were replicated in a subset of children with ADHD three months later. Our findings of divergent changes in amygdala and orbitofrontal intrinsic connectivity support the hypothesis of an impaired functional integration within the affective network in childhood ADHD. Larger prospective studies of the intrinsic affective network in ADHD are required, which may provide further insight on the biological mechanisms of emotional control deficits observed in ADHD.

PMID:
26406311
PMCID:
PMC4583510
DOI:
10.1371/journal.pone.0139018
[Indexed for MEDLINE]
Free PMC Article

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