Format

Send to

Choose Destination
J Parkinsons Dis. 2015;5(3):413-24. doi: 10.3233/JPD-150630.

Immunotherapy in Parkinson's Disease: Micromanaging Alpha-Synuclein Aggregation.

Abstract

Currently, several α-synuclein immunotherapies are being tested in experimental Parkinson's disease models and in clinical trials. Recent research has revealed that α-synuclein is not just an intracellular synaptic protein but also exists extracellularly. Moreover, the transfer of misfolded α-synuclein between cells might be a crucial step in the process leading to a progressive increase in deposition of α-synuclein aggregates throughout the Parkinson's disease brain. The revelation that α-synuclein is present outside cells has increased the interest in antibody-based therapies and opens up for the notion that microglia might play a key role in retarding Parkinson's disease progression. The objectives of this review are to describe and contrast the use of active and passive immunotherapy in treating α-synucleinopathies and highlight the likely important role of microglia in clearing misfolded α-synuclein from the extracellular space.

KEYWORDS:

Parkinson’s disease; alpha synuclein; immunotherapy; microglia

PMID:
26406122
PMCID:
PMC4923719
DOI:
10.3233/JPD-150630
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for IOS Press Icon for PubMed Central
Loading ...
Support Center