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Biomed Mater Eng. 2015;26 Suppl 1:S1265-73. doi: 10.3233/BME-151424.

Automatic detection of regions of interest in breast ultrasound images based on local phase information.

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Department of Electronic Engineering, Fudan University, Shanghai 200433, China.
Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai, China.


Due to the inherent speckling and low contrast of ultrasonic images, the accurate and efficient location of regions of interest (ROIs) is still a challenging task for breast ultrasound (BUS) computer-aided diagnosis (CAD) systems. In this paper, a fully automatic and efficient ROI generation approach is proposed. First, a BUS image is preprocessed to improve image quality. Second, a phase of max-energy orientation (PMO) image of the preprocessed image is calculated. Otsu's threshold selection method is then used to binarize the preprocessed image, the phase image and the composed image obtained by adding and normalizing the set of two images. Finally, a region selection algorithm is developed to select the true tumor region from these three binary images before generating a final ROI. The method was validated on a BUS database with 168 cases (81 benign and 87 malignant); the accuracy, average precision rate and average recall rate are calculated and compared with conventional method. The results indicate that the proposed method is more accurate and efficient in locating ROIs.


breast tumor; phase in max-energy orientation; region of interest; region selection; ultrasound image

[Indexed for MEDLINE]

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