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Oncoimmunology. 2015 Apr 2;4(9):e1026536. eCollection 2015 Sep.

A novel actor in antitumoral immunity: The thymus-specific serine protease TSSP/PRSS16 involved in CD4+ T-cell maturation.

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Inserm; U1068; CRCM ; Marseille, France ; Institut Paoli-Calmettes ; Marseille, France ; Aix-Marseille Université ; Marseille, France ; CNRS; UMR7258; CRCM ; Marseille, France.


The maturation of a specific subset of CD4+ T lymphocytes in the thymus is dependent on cortical thymic epithelial cells expressing the protease thymus-specific serine protease (TSSP, also known as PRSS16). Recently, we unveiled the involvement of TSSP in tumor suppression through its effect on the CD4+ T compartment.


CD4+ T cells; TSSP; colitis-associated colorectal cancer; thymus; tumor suppression

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