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J Rheumatol. 1989 Sep;16(9):1211-3.

The syndrome of seronegative symmetrical synovitis with pitting edema (RS3 PE syndrome): a unique form of arthritis in the elderly? Report of 4 additional cases.

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Department of Internal Medicine, Hôpital A. de Rothschild, Paris, France.


We describe 4 elderly patients who presented with peripheral seronegative inflammatory polyarthritis with pitting edema. All of these patients had a spontaneous benign evolution of their disease within 9 to 18 months. None developed erosions or relapse after prolonged followup. This particular pattern of arthritis in elderly patients might represent a separate benign clinical entity among inflammatory arthritis in aging patients.

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