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Nat Neurosci. 2015 Oct;18(10):1347-52. doi: 10.1038/nn.4111. Epub 2015 Sep 25.

Finding translation in stress research.

Author information

1
Laboratory of NeuroGenetics, Department of Psychology &Neuroscience, Duke University, Durham, North Carolina, USA.
2
Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, USA.

Abstract

In our ongoing efforts to advance understanding of human diseases, translational research across rodents and humans on stress-related mental disorders stands out as a field that is producing discoveries that illuminate mechanisms of risk and pathophysiology at a brisk rate. Here we offer a Perspective on how a productive translational research dialog between preclinical models and clinical studies of these disorders is being powered by an ever-developing appreciation of the shared neural circuits and genetic architecture that moderate the response to stress across species. Working from these deep foundations, we discuss the approaches, both traditional and innovative, that have the potential to deliver a new generation of risk biomarkers and therapeutic strategies for stress-related disorders.

PMID:
26404709
PMCID:
PMC4693288
DOI:
10.1038/nn.4111
[Indexed for MEDLINE]
Free PMC Article

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