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Nat Commun. 2015 Sep 25;6:8306. doi: 10.1038/ncomms9306.

Functional classification of memory CD8(+) T cells by CX3CR1 expression.

Author information

1
Institute of Experimental Immunology, Universitätsklinikum Bonn, Sigmund-Freud-Street 25, Bonn 53105, Germany.
2
Genomics and Immunoregulation, LIMES-Institute, Universität Bonn, Carl-Troll-Street 31, Bonn 53115, Germany.
3
Max Planck Institute of Biochemistry, Am Klopferspitz 18, München 82152, Germany.
4
Institute of Molecular Immunology and Experimental Oncology, Technische Universität München, Ismaninger Street 22, München 81675, Germany.
5
Institute of Virology, Technische Universität München, Troger Street 30, München 81675, Germany.
6
Clinic for Internal Medicine II, Universitätsklinikum Freiburg, Hugstetter Street 55, Freiburg 79106, Germany.
7
Weizmann Institute of Science, Rehovot 76100, Israel.
8
Institute of Microbiology, Immunology and Hygiene, Technische Universität München, Troger Street 30, München 81675, Germany.

Abstract

Localization of memory CD8(+) T cells to lymphoid or peripheral tissues is believed to correlate with proliferative capacity or effector function. Here we demonstrate that the fractalkine-receptor/CX3CR1 distinguishes memory CD8(+) T cells with cytotoxic effector function from those with proliferative capacity, independent of tissue-homing properties. CX3CR1-based transcriptome and proteome-profiling defines a core signature of memory CD8(+) T cells with effector function. We find CD62L(hi)CX3CR1(+) memory T cells that reside within lymph nodes. This population shows distinct migration patterns and positioning in proximity to pathogen entry sites. Virus-specific CX3CR1(+) memory CD8(+) T cells are scarce during chronic infection in humans and mice but increase when infection is controlled spontaneously or by therapeutic intervention. This CX3CR1-based functional classification will help to resolve the principles of protective CD8(+) T-cell memory.

PMID:
26404698
PMCID:
PMC4667439
DOI:
10.1038/ncomms9306
[Indexed for MEDLINE]
Free PMC Article

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