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Int J Mol Sci. 2015 Sep 2;16(9):21021-34. doi: 10.3390/ijms160921021.

Chlorella vulgaris Attenuates Dermatophagoides Farinae-Induced Atopic Dermatitis-Like Symptoms in NC/Nga Mice.

Kang H1, Lee CH2, Kim JR3,4, Kwon JY4, Seo SG5,6, Han JG7,8, Kim BG9,10, Kim JE11,12,13, Lee KW14,15,16.

Author information

1
WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea. heeerim@gmail.com.
2
WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea. changhyungds@naver.com.
3
WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea. jungykwon@snu.ac.kr.
4
Advanced Institutes of Convergence Technology, Seoul National University, Suwon 443-270, Korea. jungykwon@snu.ac.kr.
5
WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea. seo0414@naver.com.
6
Advanced Institutes of Convergence Technology, Seoul National University, Suwon 443-270, Korea. seo0414@naver.com.
7
Department of Biomaterials Science and Engineering, Yonsei University, Seoul 120-749, Korea. jaegab@daesang.com.
8
Department of Health Food Research & Development of Daesang Corp., Icheon 467-813, Korea. jaegab@daesang.com.
9
Department of Health Food Research & Development of Daesang Corp., Icheon 467-813, Korea. gonee@daesang.com.
10
Interdisplinary course of Science for Aging, Graduate School, Yonsei University, Seoul 120-749, Korea. gonee@daesang.com.
11
WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea. idonlik1@snu.ac.kr.
12
Advanced Institutes of Convergence Technology, Seoul National University, Suwon 443-270, Korea. idonlik1@snu.ac.kr.
13
Research Institute of Bio-Food Industry, Institute of Green Bio-Science and Technology, Seoul National University, Pyeongchang 232-916, Korea. idonlik1@snu.ac.kr.
14
WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea. kiwon@snu.ac.kr.
15
Advanced Institutes of Convergence Technology, Seoul National University, Suwon 443-270, Korea. kiwon@snu.ac.kr.
16
Research Institute of Bio-Food Industry, Institute of Green Bio-Science and Technology, Seoul National University, Pyeongchang 232-916, Korea. kiwon@snu.ac.kr.

Abstract

Atopic dermatitis (AD) is a chronic and inflammatory skin disease that can place a significant burden on quality of life for patients. AD most frequently appears under the age of six and although its prevalence is increasing worldwide, therapeutic treatment options are limited. Chlorella vulgaris (CV) is a species of the freshwater green algae genus chlorella, and has been reported to modulate allergy-inducible factors when ingested. Here, we examined the effect of CV supplementation on AD-like symptoms in NC/Nga mice. CV was orally administrated for six weeks while AD-like symptoms were induced via topical application of Dermatophagoides farinae extract (DFE). CV treatment reduced dermatitis scores, epidermal thickness, and skin hydration. Histological analysis also revealed that CV treatment reduced DFE-induced eosinophil and mast cell infiltration into the skin, while analysis of serum chemokine levels indicated that CV treatment downregulated thymus- and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) levels. In addition, CV treatment downregulated mRNA expression levels of IL-4 and IFN-γ. Taken together, these results suggest that CV extract may have potential as a nutraceutical ingredient for the prevention of AD.

KEYWORDS:

atopic dermatitis; chlorella vulgaris; immune cell infiltration; inflammatory cytokines; inflammatory skin lesions

PMID:
26404252
PMCID:
PMC4613239
DOI:
10.3390/ijms160921021
[Indexed for MEDLINE]
Free PMC Article

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