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Traffic. 2015 Dec;16(12):1210-38. doi: 10.1111/tra.12335. Epub 2015 Nov 6.

Forty Years of Clathrin-coated Vesicles.

Author information

1
Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

Abstract

The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975 was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered the molecular details of clathrin and its associated proteins, including how they assemble into a coated vesicle and how they select cargo. Unexpected connections have been found with signalling, development, neuronal transmission, infection, immunity and genetic disorders. But there are still a number of unanswered questions, including how clathrin-mediated trafficking is regulated and how the machinery evolved.

KEYWORDS:

adaptin; adaptor; dynamin; endocytosis; sorting signals; trans-Golgi network

PMID:
26403691
DOI:
10.1111/tra.12335
[Indexed for MEDLINE]
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