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J Biol Regul Homeost Agents. 2015 Jul-Sep;29(3):723-8.

TELOMERE AND TELOMERASE MODULATION BY BERGAMOT POLYPHENOLIC FRACTION IN EXPERIMENTAL PHOTOAGEING IN HUMAN KERATINOCYTES.

Author information

1
Department of Health Sciences; University of Catanzaro “Magna Graecia”, Italy.
2
Interregional Research Center For Food Safety and Health, Department of Health Sciences, University of Catanzaro “Magna Graecia”, Italy.
3
School of Pharmacy; University of Catanzaro “Magna Graecia”, Italy.

Abstract

Photoageing represents the addition of extrinsic chronic ultraviolet radiation-induced damage on intrinsic ageing and accounts for most age-associated changes in skin appearance. In this study, we evaluated the effect of 38% BPF, a highly concentrated extract of the bergamot fruit (Citrus bergamia) on UVB-induced photoageing by examining inflammatory cytokine expression, telomere length/telomerase alterations and cellular viability in human immortalized HaCaT keratinocytes. Our results suggest that 38% BPF protects HaCaT cells against UVB-induced oxidative stress and markers of photoageing in a dose-dependent manner and could be a useful supplement in skin care products. Together with antioxidant properties, BPF, a highly concentrated extract of the bergamot fruit, appears to modulate basic cellular signal transduction pathways leading to anti-proliferative, anti-aging and immune modulating responses.

PMID:
26403416
[Indexed for MEDLINE]

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