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J Biol Regul Homeost Agents. 2015 Jul-Sep;29(3):563-7.

IMMUNOMODULATORY EFFECTS OF VITAMIN D ON SKIN INFLAMMATION.

Author information

1
Department of Medical, Oral and Biotechnological Sciences, University G. D’Annunzio, Chieti- Pescara, Italy.
2
Department of Surgery and Odontostomatological Sciences, University of Cagliari, Italy.
3
Department of Dermatology, University of Rome Tor Vergata, Rome, Italy.
4
Department of Microbiology and Infectious Diseases, School of Veterinary Medicine, Aristotle University of Thessaloniki, Macedonia, Greece.
5
Orthopedic Division, University of Perugia, Perugia, Italy.
6
Department of Neurosciences and Imaging, Faculty of Medicine and Surgery, G. D’Annunzio University Chieti-Pescara, Chieti, Italy.
7
Catholic University of Rome, Italy.
8
Immunology Division, Post Graduate School of Medicine, Chieti, Italy.

Abstract

Vitamin D has a major role in calcium absorption and maintenance of healthy bones. Vitamin D is also involved in cancer, cardiovascular system, allergic diseases, immune regulation and immune disor¬ders. Irradiation of food as well as animals produces vitamin D and more than 90% of previtamin D3 synthesis in the skin occurs in the epidermis. Vitamin D receptor has been found in many cells including T and B lymphocytes, macrophages, mast cells, NK cells and Tregs, and it selectively binds with high affinity to its ligand. Vitamin D binds its receptor VDR, resulting in transcription of a number of genes playing a role in inhibition of MAPK. Its effect may be also mediated by the direct activation of PKC. Vitamin D has the ability to suppress inflammatory cytokines such as TNF, IL-1, IFN-gamma and IL-2; while it increases the generation of anti-inflammatory cytokines IL-4 and IL-10. In B cells, vitamin D3 have also been shown to suppress IgE antibody class switch partly through the inhibition of NF-kB. Here we discuss the relationship between vitamin D, immunity and skin disorders.

PMID:
26403394
[Indexed for MEDLINE]

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