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Nutrients. 2015 Sep 21;7(9):8127-51. doi: 10.3390/nu7095383.

Regulation of Dendritic Cell Function by Vitamin D.

Barragan M1,2,3, Good M4,5,6, Kolls JK7,8.

Author information

1
Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA. Myriam.Barragan@bcm.edu.
2
Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA. Myriam.Barragan@bcm.edu.
3
Department of Pediatrics, School of Medicine, University of Pittsburgh Pittsburgh, PA 15224, USA. Myriam.Barragan@bcm.edu.
4
Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA. goodml3@upmc.edu.
5
Department of Pediatrics, School of Medicine, University of Pittsburgh Pittsburgh, PA 15224, USA. goodml3@upmc.edu.
6
Division of Newborn Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15224, USA. goodml3@upmc.edu.
7
Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA. jay.kolls@chp.edu.
8
Department of Pediatrics, School of Medicine, University of Pittsburgh Pittsburgh, PA 15224, USA. jay.kolls@chp.edu.

Abstract

Studies over the last two decades have revealed profound immunomodulatory aspects of vitamin D on various aspects of the immune system. This review will provide an overview of Vitamin D metabolism, a description of dendritic cell subsets, and highlight recent advances on the effects of vitamin D on dendritic cell function, maturation, cytokine production and antigen presentation. The active form of vitamin D, 1,25(OH)₂D₃, has important immunoregulatory and anti-inflammatory effects. Specifically, the 1,25(OH)₂D₃-Vitamin D₃ complex can affect the maturation and migration of many dendritic cell subsets, conferring a special immunoregulatory role as well as tolerogenic properties affecting cytokine and chemokine production. Furthermore, there have been many recent studies demonstrating the effects of Vitamin D on allergic disease and autoimmunity. A clear understanding of the effects of the various forms of Vitamin D will provide new opportunities to improve human health.

KEYWORDS:

cytokines; dendritic cells; inflammation; innate and adaptive immunity; interleukins; vitamin D; vitamin D receptor

PMID:
26402698
PMCID:
PMC4586578
DOI:
10.3390/nu7095383
[Indexed for MEDLINE]
Free PMC Article

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