Format

Send to

Choose Destination
Elife. 2015 Sep 24;4:e08723. doi: 10.7554/eLife.08723.

Competing basal ganglia pathways determine the difference between stopping and deciding not to go.

Author information

1
Department of Psychology, University of Pittsburgh, Pittsburgh, United States.
2
Center for the Neural Basis of Cognition, University of Pittsburgh and Carnegie Mellon University, Pittsburgh, United States.
3
Department of Psychology, Carnegie Mellon University, Pittsburgh, United States.

Abstract

The architecture of corticobasal ganglia pathways allows for many routes to inhibit a planned action: the hyperdirect pathway performs fast action cancellation and the indirect pathway competitively constrains execution signals from the direct pathway. We present a novel model, principled off of basal ganglia circuitry, that differentiates control dynamics of reactive stopping from intrinsic no-go decisions. Using a nested diffusion model, we show how reactive braking depends on the state of an execution process. In contrast, no-go decisions are best captured by a failure of the execution process to reach the decision threshold due to increasing constraints on the drift rate. This model accounts for both behavioral and functional MRI (fMRI) responses during inhibitory control tasks better than alternative models. The advantage of this framework is that it allows for incorporating the effects of context in reactive and proactive control into a single unifying parameter, while distinguishing action cancellation from no-go decisions.

KEYWORDS:

basal ganglia; computational biology; decision making; human; inhibitory control; neuroscience; systems biology

PMID:
26402462
PMCID:
PMC4686424
DOI:
10.7554/eLife.08723
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for eLife Sciences Publications, Ltd Icon for PubMed Central
Loading ...
Support Center