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J Alzheimers Dis. 2015;48(2):355-9. doi: 10.3233/JAD-150168.

Age-Stratified Prevalence of Mild Cognitive Impairment and Dementia in European Populations: A Systematic Review.

Author information

1
Roche Products Limited, Hexagon Place, 6 Falcon way, Shire Park, Welwyn Garden City, UK.
2
Institute of Psychiatry, King's College London, De Crespigny Park, London, UK.
3
Janssen Pharmaceutical Research and Development, Titusville, NJ, USA.
4
Janssen Research & Development, LLC, Fremont, CA, USA.
5
Boehringer Ingelheim, Reims, France.
6
Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA.

Abstract

The prevalence of mild cognitive impairment (MCI) and dementia according to age remain uncertain. We systematically extracted age-stratified estimates of MCI and dementia prevalence reported in European studies published since 1995, and performed meta-analyses for dementia. We identified 10 relevant studies on MCI and 26 studies on dementia. Studies on MCI presented substantial heterogeneity preventing a meta-analysis, with a majority reporting an increase in prevalence at ≥75 years old. Pooled prevalence of dementia rose continuously from 55 years of age, reaching 44.7% (39.8; 49.6) in those ≥95 years of age. Homogenization of MCI criteria, and additional studies in Northern European population would be warranted.

KEYWORDS:

Dementia; epidemiology; mild cognitive impairment; prevalence

PMID:
26401999
DOI:
10.3233/JAD-150168
[Indexed for MEDLINE]

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