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J Alzheimers Dis. 2015;47(4):877-81. doi: 10.3233/JAD-150179.

Mirror Image of the Amyloid-β Species in Cerebrospinal Fluid and Cerebral Amyloid in Alzheimer's Disease.

Author information

1
Division of Neurology 5 and Neuropathology, IRCCS Foundation - Carlo Besta Neurological Institute, Milan, Italy.
2
Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio - Fatebenefratelli, Brescia, Italy.

Abstract

Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) accumulation in brain that is paralleled by Aβ(1-42) reduction in cerebrospinal fluid (CSF). We analyzed the pattern of Aβ peptides, including the N- and C-terminal truncated fragments, in brain and CSF from two familial and one sporadic AD cases. We found that (i) each patient is characterized by a distinct Aβ profile in CSF and brain deposits and (ii) the CSF Aβ pattern mirrors the Aβ profile of cerebral amyloid. These results suggest the existence of different molecular AD subtypes which can be recognized by CSF analysis, enabling patient stratification.

KEYWORDS:

Alzheimer’s disease; SELDI-TOF MS; amyloid-β; biomarker; cerebrospinal fluid

PMID:
26401767
DOI:
10.3233/JAD-150179
[Indexed for MEDLINE]

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