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J Alzheimers Dis. 2015;47(2):323-7. doi: 10.3233/JAD-150304.

MTHFR Gene Mutations: A Potential Marker of Late-Onset Alzheimer's Disease?

Abstract

Recent epigenome-wide association studies have confirmed the importance of epigenetic effects mediated by DNA methylation in late-onset Alzheimer's disease (LOAD). Metabolic folate pathways and methyl donor reactions facilitated by B-group vitamins may be critical in the pathogenesis of LOAD. Methylenetetrahydrofolate reductase (MTHFR) gene mutations were studied in consecutive Alzheimer's Disease & Memory Clinic patients up to December 2014. DNA analyses of MTHFR-C667T and - A1298C homozygous and heterozygous polymorphisms in 93 consecutive elderly patients revealed high prevalence of MTHFR mutations (92.5%). Findings require confirmation in a larger series, but MTHFR mutations may become a LOAD marker, opening novel possibilities for prevention and treatment.

KEYWORDS:

Alzheimer’s disease; DNA methylation; MTHFR gene; epigenetics; vitamins B-group

PMID:
26401555
DOI:
10.3233/JAD-150304
[Indexed for MEDLINE]

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