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J Infect Dis. 2016 Feb 15;213(4):669-73. doi: 10.1093/infdis/jiv467. Epub 2015 Sep 23.

Helicobacter pylori cagA Promoter Region Sequences Influence CagA Expression and Interleukin 8 Secretion.

Author information

1
i3S - Instituto de Investigação e Inovação em Saúde Ipatimup - Institute of Molecular Pathology and Immunology.
2
Ipatimup - Institute of Molecular Pathology and Immunology Centro Hospitalar Vila Nova de Gaia/Espinho, Portugal.
3
Institute of Biomedical Sciences Abel Salazar CIDES/CINTESIS Department of Gastroenterology, Centro Hospitalar do Porto.
4
CIDES/CINTESIS Department of Gastroenterology, IPO.
5
i3S - Instituto de Investigação e Inovação em Saúde Ipatimup - Institute of Molecular Pathology and Immunology Faculty of Medicine, University of Porto Department of Pathology, Centro Hospitalar São João, Porto.
6
i3S - Instituto de Investigação e Inovação em Saúde Ipatimup - Institute of Molecular Pathology and Immunology Faculty of Medicine, University of Porto.

Abstract

Heterogeneity at the Helicobacter pylori cagA gene promoter region has been linked to variation in CagA expression and gastric histopathology. Here, we characterized the cagA promoter and expression in 46 H. pylori strains from Portugal. Our results confirm the relationship between cagA promoter region variation and protein expression originally observed in strains from Colombia. We observed that individuals with intestinal metaplasia were all infected with H. pylori strains containing a specific cagA motif. Additionally, we provided novel functional evidence that strain-specific sequences in the cagA promoter region and CagA expression levels influence interleukin 8 secretion by the host gastric epithelial cells.

KEYWORDS:

CagA expression; Helicobacter pylori; IL-8; cagA promoter region

PMID:
26401027
DOI:
10.1093/infdis/jiv467
[Indexed for MEDLINE]

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