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Mol Diagn Ther. 2015 Dec;19(6):339-50. doi: 10.1007/s40291-015-0167-y.

Role of Circulating Cell-Free DNA in Cancers.

Author information

1
Department of Molecular Oncology, Cancer Institute (WIA), Chennai, 600036, India.
2
Department of Surgical Oncology, Cancer Institute (WIA), Chennai, India.
3
Department of Onco-pathology, Cancer Institute (WIA), Chennai, India.
4
Department of Molecular Oncology, Cancer Institute (WIA), Chennai, 600036, India. drtrajkumar@gmail.com.

Abstract

Liquid biopsy is a term used to describe non-invasive tests, which provide information about disease conditions through analysis of circulating cell-free DNA and circulating tumor cells from peripheral blood samples. In patients with cancer, the concentration of cell-free DNA increases, and structural, sequence, and epigenetic changes to DNA can be observed through the disease process and during therapy. Furthermore, cell-free DNA released by the tumor contains the same variants as those in the tumor cells. Therefore, cell-free DNA allows non-invasive assessment of cancer in real time. This review summarizes the origin of cell-free DNA, recent advancements in the detection of cell-free DNA, a possible role in metastasis, and its importance as a non-invasive diagnostic assay for cancer.

PMID:
26400814
DOI:
10.1007/s40291-015-0167-y
[Indexed for MEDLINE]

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