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Cerebellum. 2016 Aug;15(4):526-34. doi: 10.1007/s12311-015-0722-4.

Are Purkinje Cell Pauses Drivers of Classically Conditioned Blink Responses?

Author information

1
Department of Experimental Medical Science, Lund University, BMC F10, 22184, Lund, Sweden. Dan-Anders.Jirenhed@med.lu.se.
2
Department of Experimental Medical Science, Lund University, BMC F10, 22184, Lund, Sweden.

Abstract

Several lines of evidence show that classical or Pavlovian conditioning of blink responses depends on the cerebellum. Recordings from cerebellar Purkinje cells that control the eyelid and the conditioned blink show that during training with a conditioning protocol, a Purkinje cell develops a pause response to the conditional stimulus. This conditioned cellular response has many of the properties that characterise the overt blink. The present paper argues that the learned Purkinje cell pause response is the memory trace and main driver of the overt conditioned blink and that it explains many well-known behavioural phenomena.

KEYWORDS:

Cerebellum; Classical conditioning; Purkinje cells; Simple spikes; Timing

PMID:
26400585
PMCID:
PMC4923092
DOI:
10.1007/s12311-015-0722-4
[Indexed for MEDLINE]
Free PMC Article

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