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Nucleic Acids Res. 2016 Jan 4;44(D1):D757-63. doi: 10.1093/nar/gkv963. Epub 2015 Sep 22.

hPSCreg--the human pluripotent stem cell registry.

Author information

1
Berlin-Brandenburg Center for Regenerative Therapies, Charité University Medicine Berlin, Berlin, 13353, Germany.
2
Berlin-Brandenburg Center for Regenerative Therapies, Charité University Medicine Berlin, Berlin, 13353, Germany Berlin Institute of Health-Stem Cell Core Facility, 13353 Berlin, Germany.
3
National Institute for Biological Standards and Control, South Mimms EN63QG, UK.
4
Center of Regenerative Medicine in Barcelona, Barcelona Stem Cell Bank, Barcelona 08003, Spain.
5
Berlin-Brandenburg Center for Regenerative Therapies, Charité University Medicine Berlin, Berlin, 13353, Germany Seoul National University, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul 151-742, Republic of Korea andreas.kurtz@charite.de.

Abstract

The human pluripotent stem cell registry (hPSCreg), accessible at http://hpscreg.eu, is a public registry and data portal for human embryonic and induced pluripotent stem cell lines (hESC and hiPSC). Since their first isolation the number of hESC lines has steadily increased to over 3000 and new iPSC lines are generated in a rapidly growing number of laboratories as a result of their potentially broad applicability in biomedicine and drug testing. Many of these lines are deposited in stem cell banks, which are globally established to store tens of thousands of lines from healthy and diseased donors. The Registry provides comprehensive and standardized biological and legal information as well as tools to search and compare information from multiple hPSC sources and hence addresses a translational research need. To facilitate unambiguous identification over different resources, hPSCreg automatically creates a unique standardized name for each cell line registered. In addition to biological information, hPSCreg stores extensive data about ethical standards regarding cell sourcing and conditions for application and privacy protection. hPSCreg is the first global registry that holds both, manually validated scientific and ethical information on hPSC lines, and provides access by means of a user-friendly, mobile-ready web application.

PMID:
26400179
PMCID:
PMC4702942
DOI:
10.1093/nar/gkv963
[Indexed for MEDLINE]
Free PMC Article

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