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PLoS One. 2015 Sep 23;10(9):e0138461. doi: 10.1371/journal.pone.0138461. eCollection 2015.

Inflammation, Endothelial Dysfunction and Increased Left Ventricular Mass in Chronic Kidney Disease (CKD) Patients: A Longitudinal Study.

Author information

1
Nephrology Department, Nicosia General Hospital, Nicosia, Cyprus.
2
ERA-EDTA Registry, Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
3
Department of Nephrology, Medical School, University of Ioannina, Ioannina, Greece.
4
Department of Nephrology, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece.
5
Department of Cardiology, University Hospital of Ioannina, Ioannina, Greece.
6
CNR-IBIM Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension, Renal and Transplantation Unit, Reggio Calabria, Italy.
7
Department of Nephrology, Papageorgiou General Hospital of Thessaloniki, Thessaloniki, Greece.

Abstract

INTRODUCTION:

Within this longitudinal study we investigated the association of inflammation markers C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNFα) and endothelial dysfunction markers intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) with left ventricular mass indexed for height(2.71) (LVMI) in hypertensive predialysis CKD patients.

MATERIAL AND METHODS:

From 2004 to 2005, 182 incident consecutive adult patients from the outpatient CKD clinics of two hospitals in Greece with CKD and hypertension or using antihypertensive medication, were included. Of these, 107 patients underwent CRP (mg/l) and LVMI (g/height(2.71)) measurements annually for three years.

RESULTS:

In the longitudinal analyses, using linear mixed modeling, a higher IL-6 (ß = 1.9 (95%ci:0.38;3.5), inflammation score based on CRP, IL-6 and TNF-α (ß = 5.0 (95%ci:0.72; 9.4) and VCAM-1 (ß = 0.01 (95%ci:0.005;0.02) were associated with higher LVMI. These models were adjusted for age, gender and primary renal disease, and for confounders that on top changed the beta with ≥ 10%, i.e. diuretic use (for IL-6 and inflammation score).

CONCLUSION:

The results suggest that in predialysis CKD patients, inflammation as well as endothelial dysfunction may play an important role towards the increase in LVMI.

PMID:
26398099
PMCID:
PMC4580570
DOI:
10.1371/journal.pone.0138461
[Indexed for MEDLINE]
Free PMC Article

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