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Eur Radiol. 2016 Jun;26(6):1705-15. doi: 10.1007/s00330-015-4025-4. Epub 2015 Sep 22.

Combination of diffusion tensor imaging and conventional MRI correlates with isocitrate dehydrogenase 1/2 mutations but not 1p/19q genotyping in oligodendroglial tumours.

Author information

1
Department of Radiology, Huashan Hospital of Fudan University, No. 12 the Middle Wu Lu Mu Qi Road, Shanghai, 200040, China.
2
Department of Neuropathology, Huashan Hospital of Fudan University, Shanghai, China.
3
Department of Radiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
4
Department of Radiology, Huashan Hospital of Fudan University, No. 12 the Middle Wu Lu Mu Qi Road, Shanghai, 200040, China. zhj81828@163.com.
5
Department of Radiology, Huashan Hospital of Fudan University, No. 12 the Middle Wu Lu Mu Qi Road, Shanghai, 200040, China. daoyinggeng@163.com.

Abstract

OBJECTIVES:

To explore the correlations of conventional MRI (cMRI) and diffusion tensor imaging (DTI) values with the 1p/19 codeletion and IDH mutations in oligodendroglial tumours (OTs).

METHODS:

Eighty-four patients with OTs who underwent cMRI and DTI were retrospectively reviewed. The maximal fractional anisotropy and minimal apparent diffusion coefficient (ADC) were measured and compared using the Mann-Whitney U test. Receiver operating characteristic curves, logistic regression analysis and four-table statistics analysis were performed to predict genotypings.

RESULTS:

OTs with 1p/19q codeletion or IDH mutations were prone to locate in frontal (P = 0.106 and 0.005, respectively) and insular lobes and were associated with absent or blurry contrast enhancement (P = 0.040 and 0.013, respectively). DTI values showed significant differences between OTs with and without IDH mutations (P < 0.05) but not in OTs with and without 1p/19q loss. The Ki-67 index significantly correlated with IDH mutations (P = 0.002) but not with 1p/19q codeletion. A combination of DTI and cMRI for the identification of IDH mutations resulted in sensitivity, specificity, positive and negative predictive values of 92.2 %, 75.8 %, 93.8 % and 71.1 %, respectively.

CONCLUSIONS:

Combination of DTI and cMRI correlates with isocitrate dehydrogenase 1/2 mutations but not 1p/19q genotyping in OTs.

KEY POINTS:

• OTs with 1p/19q codeletion were associated with absent or blurry contrast enhancement • OTs with IDH mutations were also associated with absent or blurry contrast enhancement • OTs with IDH mutations were prone to locate in frontal and insular lobes • DTI values can provide a non-invasive method for assessing the IDH status of OTs • A combination of DTI and cMRI correlates with isocitrate dehydrogenase 1/2 mutations.

KEYWORDS:

1p/19q codeletion; Conventional MRI; Diffusion tensor imaging; Isocitrate dehydrogenase gene; Oligodendroglial tumours

PMID:
26396108
DOI:
10.1007/s00330-015-4025-4
[Indexed for MEDLINE]

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