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Appl Microbiol Biotechnol. 2015 Dec;99(23):9847-63. doi: 10.1007/s00253-015-6941-2. Epub 2015 Sep 22.

Biological activities of ribosome-inactivating proteins and their possible applications as antimicrobial, anticancer, and anti-pest agents and in neuroscience research.

Author information

1
Department of Biology and Medical Laboratory Research, Faculty of Technology, University of Applied Sciences Leiden, Zernikdreef 11, 2333 CK, Leiden, The Netherlands. ouafae@live.nl.
2
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. b021770@mailserv.cuhk.edu.hk.
3
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. chifaicheung@cuhk.edu.hk.
4
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. b110590@mailserv.cuhk.edu.hk.
5
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. wenliangp@sina.com.
6
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. charlene.cw.ng@gmail.com.
7
School of Medicine, Shenzhen University Health Science Centre, Shenzhen University, Shenzhen, China. shaou@szu.edu.cn.
8
School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. pcshaw@cuhk.edu.hk.
9
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. chanwy@cuhk.edu.hk.

Abstract

Ribosome-inactivating proteins (RIPs) are enzymes which depurinate ribosomal RNA (rRNA), thus impeding the process of translation resulting in inhibition of protein synthesis. They are produced by various organisms including plants, fungi and bacteria. RIPs from plants are linked to plant defense due to their antiviral, antifungal, antibacterial, and insecticidal activities in which they can be applied in agriculture to combat microbial pathogens and pests. Their anticancer, antiviral, embryotoxic, and abortifacient properties may find medicinal applications. Besides, conjugation of RIPs with antibodies or other carriers to form immunotoxins has been found useful to research in neuroscience and anticancer therapy.

KEYWORDS:

Anticancer; Antifungal; Antiviral; Insecticidal; Ribosome-inactivating proteins

PMID:
26394859
DOI:
10.1007/s00253-015-6941-2
[Indexed for MEDLINE]

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