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Sci Rep. 2015 Sep 23;5:14302. doi: 10.1038/srep14302.

Enterovirus 71 2C Protein Inhibits NF-κB Activation by Binding to RelA(p65).

Author information

1
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100176, PR China.
2
Shanghai Municipal Center for Disease Control &Prevention, Shanghai 200336, China.

Abstract

Viruses evolve multiple ways to interfere with NF-κB signaling, a key regulator of innate and adaptive immunity. Enterovirus 71 (EV71) is one of primary pathogens that cause hand-foot-mouth disease. Here, we identify RelA(p65) as a novel binding partner for EV71 2C protein from yeast two-hybrid screen. By interaction with IPT domain of p65, 2C reduces the formation of heterodimer p65/p50, the predominant form of NF-κB. We also show that picornavirus 2C family proteins inhibit NF-κB activation and associate with p65 and IKKβ. Our findings provide a novel mechanism how EV71 antagonizes innate immunity.

PMID:
26394554
PMCID:
PMC4585786
DOI:
10.1038/srep14302
[Indexed for MEDLINE]
Free PMC Article

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