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Adv Mater. 2015 Nov 4;27(41):6382-9. doi: 10.1002/adma.201503381. Epub 2015 Sep 22.

A Prussian Blue-Based Core-Shell Hollow-Structured Mesoporous Nanoparticle as a Smart Theranostic Agent with Ultrahigh pH-Responsive Longitudinal Relaxivity.

Author information

1
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 200050, Shanghai, P. R. China.
2
Second Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, P. R. China.

Abstract

Novel core-shell hollow mesoporous Prussian blue @ Mn-containing Prussian blue analogue (HMPB@MnPBA) nanoparticles, designated as HMPB-Mn) as an intelligent theranostic nanoagent, are successfully constructed by coating a similarly crystal-structured MnPBA onto HMPB. This can be used as a pH-responsive T1 -weighted magnetic resonance imaging contrast agent with ultrahigh longitudinal relaxivity (r1 = 7.43 m m(-1) s(-1) ), and achieves the real-time monitoring of drug release.

KEYWORDS:

Prussian blue; magnetic resonance imaging; manganese; pH-responsive; theranostics

PMID:
26393889
DOI:
10.1002/adma.201503381
[Indexed for MEDLINE]

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