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Antimicrob Agents Chemother. 2015 Dec;59(12):7823-5. doi: 10.1128/AAC.01021-15. Epub 2015 Sep 21.

Microbiological Assessment of Polymyxin B Components Tested Alone and in Combination.

Author information

1
Department of Pharmaceutical Services, University of California, Los Angeles, Los Angeles, California, USA.
2
Department of Clinical Services and Administration, University of Houston, Houston, Texas, USA.
3
Colleges of Pharmacy and Medicine, University of Illinois at Chicago, Chicago, Illinois, USA danziger@uic.edu.
4
Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
5
JMI Laboratories, North Liberty, Iowa, USA.

Abstract

We investigated the antimicrobial activity of four polymyxin B components, B1, B2, B3, and isoleucine (Ile)-B1, individually and in combination. B3 was the most active agent against all organisms tested except Acinetobacter baumannii, for which Ile-B1 was most active. One combination met the criteria for synergy, B3 plus Ile-B1. No combinations exhibited antagonism. The dominant components of polymyxin B products (B1 and B2) were associated with the lowest probability of improved antibacterial activity when combined.

PMID:
26392511
PMCID:
PMC4649206
DOI:
10.1128/AAC.01021-15
[Indexed for MEDLINE]
Free PMC Article

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