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Acta Neurol Scand. 2016 Jul;134(1):35-41. doi: 10.1111/ane.12504. Epub 2015 Sep 22.

Different fates of excessive daytime sleepiness: survival analysis for remission.

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Department of Neuropsychiatry, Seoul National University Bundang Hospital, Gyeonggi-do, Korea.
Department of Psychiatry, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.



Excessive daytime sleepiness (EDS) is a symptom frequently presented in sleep clinics. Only a paucity of data has addressed clinical courses of sleep disorders with EDS. Therefore, we sought to compare clinical outcomes of patients presenting EDS.


A retrospective observational study was performed in the setting of sleep laboratory and outpatient department in a university hospital. One hundred and eight patients who presented EDS underwent polysomnography and multiple sleep latency test. Each patient was diagnosed as one of the following four categories: (1) narcolepsy with cataplexy (N + C; n = 29); (2) narcolepsy without cataplexy (N - C; n = 22); (3) idiopathic hypersomnia (IH; n = 24); and (4) subjective hypersomnolence (SH; n = 33) with mean sleep latency >8 min. Remission of EDS and treatment response were determined based on clinical evaluation. Kaplan-Meier survival analysis was performed.


Remission rates were significantly different (P < 0.001, overall log-rank test) among four groups except those between N - C and IH (P = 0.489). While N + C showed no remission, predicted remission rates of N - C and IH group were 44.6% at 5 years and 32.5% at 5.5 years after diagnosis. The predicted remission rate of SH group was 71.7% at 3 years after diagnosis.


The similarity of clinical courses between N - C and IH suggests that N - C may be more related to IH compared to N + C. Considering different clinical courses among EDS patients, thorough evaluation of EDS should be warranted before starting treatment.


excessive daytime sleepiness; idiopathic hypersomnia; narcolepsy; remission

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