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Behav Brain Res. 2016 Jan 1;296:290-300. doi: 10.1016/j.bbr.2015.09.024. Epub 2015 Sep 21.

Protective effect of the orientin on noise-induced cognitive impairments in mice.

Author information

1
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China.
2
Schizophrenia Research Institute (SRI), 405 Liverpool St., Sydney, NSW 2010, Australia; Illawarra Health and Medical Research Institute, School of Medicine, University of Wollongong, NSW 2522, Australia.
3
Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: fugle99@126.com.
4
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: cbpeliuyinew@163.com.

Abstract

There is increasing evidence that chronic noise stress impairs cognition and induces oxidative stress in the brain. Recently, orientin, a phenolic compound abundant in some fruits, millet, and herbs, has been shown to have antioxidant properties. This study investigated the potential effects of orientin against chronic noise-induced cognitive decline and its underlying mechanisms. A moderate-intensity noise exposure model was used to investigate the effects of orientin on behavior and biochemical alterations in mice. After 3 weeks of the noise exposure, the mice were treated with orientin (20mg/kg and 40 mg/kg, oral gavage) for 3 weeks. The chronic noise exposure impaired the learning and memory in mice in the Morris water maze and step-through tests. The noise exposure also decreased exploration and interest in a novel environment in the open field test. The administration of orientin significantly reversed noise-induced alterations in these behavior tests. Moreover, the orientin treatment significantly improved the noise-induced alteration of serum corticosterone and catecholamine levels and oxidative stress in the hippocampus and prefrontal cortex. Furthermore, the orientin treatment ameliorated the noise-induced decrease in brain-derived neurotrophic factor and synapse-associated proteins (synaptophysin and postsynaptic density protein 95) in the hippocampus and prefrontal cortex. Thus, orientin exerts protective effects on noise-induced cognitive decline in mice, specifically by improving central oxidative stress, neurotransmission, and increases synapse-associated proteins. Therefore, supplementation with orientin-enriched food or fruit could be beneficial as a preventive strategy for chronic noise-induced cognitive decline.

KEYWORDS:

Cognitive impairments; Orientin; Oxidative stress; Synaptic-associated plasticity

PMID:
26392065
DOI:
10.1016/j.bbr.2015.09.024
[Indexed for MEDLINE]

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