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J Am Heart Assoc. 2015 Sep 21;4(9):e001802. doi: 10.1161/JAHA.115.001802.

Plasma Inflammatory Markers and the Risk of Developing Hypertension in Men.

Author information

1
Division of Preventive Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA (H.D.S., M.C.J., L.W., P.M.R., J.E.B., M.G.) Division of Aging, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA (H.D.S., J.E.B., M.G.) Department of Epidemiology, Harvard School of Public Health, Boston, MA (H.D.S., J.E.B.).
2
Division of Preventive Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA (H.D.S., M.C.J., L.W., P.M.R., J.E.B., M.G.).
3
Division of Preventive Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA (H.D.S., M.C.J., L.W., P.M.R., J.E.B., M.G.) Division of Aging, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA (H.D.S., J.E.B., M.G.).

Abstract

BACKGROUND:

Several cross-sectional, but few prospective, studies suggest that inflammation may be involved in the development of hypertension. We examined markers of inflammation-high-sensitivity C-reactive protein, interleukin-6, and soluble intercellular adhesion molecule-1-and a marker of fibrinolysis, D-dimer, for their associations with incident hypertension in the Physicians' Health Study.

METHODS AND RESULTS:

Baseline blood values and information on hypertension-related risk factors were collected in 1982. Incident hypertension was defined as self-reported initiation of antihypertensive treatment, systolic blood pressure ≥140 mm Hg, or diastolic blood pressure ≥90 mm Hg during follow-up. With use of a nested case-control design, 396 cases of incident hypertension and controls free of hypertension were matched 1:1 on age (mean 47.4 years) and follow-up time. In crude matched-pair analyses, the conditional relative risks of hypertension in the second through fourth versus the lowest quartiles for plasma high-sensitivity C-reactive protein were 1.27, 1.73, and 1.81 (Ptrend=0.01); for interleukin-6, 1.22, 1.02, and 1.51 (Ptrend=0.06); for soluble intercellular adhesion molecule-1, 1.00, 0.80, and 1.26 (Ptrend=0.37); and for D-dimer, 1.61, 1.81, and 1.52 (Ptrend=0.46). Multivariable adjustment attenuated the estimates. The multivariable relative risks of hypertension in the second through fourth compared to the lowest quartiles of high-sensitivity C-reactive protein were 1.24, 1.60, and 1.47 (Ptrend=0.20); for interleukin-6, 1.08, 0.92, and 1.36 (Ptrend=0.16); for soluble intercellular adhesion molecule-1, 0.89, 0.79, and 1.18 (Ptrend=0.55); and for D-dimer, 1.48, 1.68, and 1.38 (Ptrend=0.63).

CONCLUSIONS:

Elevated plasma inflammatory markers and D-dimer were nonsignificantly associated with a higher risk of hypertension among initially healthy men.

KEYWORDS:

blood pressure; hypertension; inflammation; men; prospective studies

PMID:
26391130
PMCID:
PMC4599490
DOI:
10.1161/JAHA.115.001802
[Indexed for MEDLINE]
Free PMC Article

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