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Gene. 2016 Jan 10;575(2 Pt 3):577-83. doi: 10.1016/j.gene.2015.09.029. Epub 2015 Sep 24.

Structure and functional roles of Epac2 (Rapgef4).

Author information

1
Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan; Division of Molecular and Metabolic Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
2
Division of Molecular and Metabolic Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
3
Division of Molecular and Metabolic Medicine, Kobe University Graduate School of Medicine, Kobe, Japan. Electronic address: seino@med.kobe-u.ac.jp.

Abstract

Epac (exchange protein activated by cyclic-AMP) 2 is a direct target of 3'-5'-cyclic adenosine monophosphate (cAMP) and is involved in cAMP-mediated signal transduction through activation of the Ras-like small GTPase Rap. Crystallographic analyses revealed that activation of Epac2 by cAMP is accompanied by dynamic structural changes. Epac2 is expressed mainly in brain, neuroendocrine and endocrine tissues, and is involved in diverse cellular functions in the tissues. In this review, we summarize the structure and function of Epac2. We also discuss the physiological and pathophysiological roles of Epac2, and the possibility of Epac2 as a therapeutic target.

KEYWORDS:

Epac2; Rap; cAMP

PMID:
26390815
PMCID:
PMC6636354
DOI:
10.1016/j.gene.2015.09.029
[Indexed for MEDLINE]
Free PMC Article

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