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Nat Genet. 2015 Nov;47(11):1282-1293. doi: 10.1038/ng.3405. Epub 2015 Sep 21.

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.

Kato N#1, Loh M#2,3,4, Takeuchi F#1, Verweij N#5, Wang X#6, Zhang W#3,7, Kelly TN#8, Saleheen D#9,10,11, Lehne B#3, Leach IM#5, Drong AW12, Abbott J13, Wahl S14,14,15, Tan ST7,16, Scott WR3,16, Campanella G3, Chadeau-Hyam M3, Afzal U3,7, Ahluwalia TS17,18,19, Bonder MJ20, Chen P6, Dehghan A21, Edwards TL22, Esko T23,24,25,26, Go MJ27, Harris SE28,29, Hartiala J30,31, Kasela S23, Kasturiratne A32, Khor CC6,33,34,35, Kleber ME36, Li H37, Yu Mok Z38, Nakatochi M39, Sapari NS38, Saxena R40, Stewart AFR41,42, Stolk L43, Tabara Y44, Teh AL45, Wu Y46, Wu JY47,48, Zhang Y49,50, Aits I51, Da Silva Couto Alves A52, Das S52, Dorajoo R33, Hopewell JC53, Kim YK27, Koivula RW54, Luan J55, Lyytikäinen LP56,57, Nguyen QN58, Pereira MA59, Postmus I60,61, Raitakari OT62,63, Bryan MS64, Scott RA55, Sorice R65, Tragante V66, Traglia M67,68, White J69, Yamamoto K70, Zhang Y71, Adair LS72, Ahmed A73, Akiyama K1, Asif R9, Aung T74, Barroso I75,76,77, Bjonnes A40, Braun TR78, Cai H79,80, Chang LC47, Chen CH47,48, Cheng CY6,34,74,81, Chong YS45,82, Collins R53, Courtney R79,80, Davies G29,83, Delgado G36, Do LD58, Doevendans PA66, Gansevoort RT84, Gao YT85, Grammer TB36, Grarup N17, Grewal J3,7, Gu D86, Wander GS87, Hartikainen AL88,89,90, Hazen SL91,92, He J93, Heng CK94, Hixson JE95, Hofman A21, Hsu C96, Huang W97, Husemoen LLN98, Hwang JY27, Ichihara S99, Igase M100, Isono M1, Justesen JM17, Katsuya T101,102, Kibriya MG64, Kim YJ27, Kishimoto M103, Koh WP6,104, Kohara K100, Kumari M105, Kwek K106, Lee NR107,108, Lee J6, Liao J34,74, Lieb W51, Liewald DCM29,83, Matsubara T109, Matsushita Y103, Meitinger T110,111, Mihailov E23, Milani L23, Mills R7, Mononen N56,57, Müller-Nurasyid M112,113,114, Nabika T115, Nakashima E116,117, Ng HK38, Nikus K118, Nutile T65, Ohkubo T119, Ohnaka K120, Parish S53, Paternoster L121, Peng H71, Peters A122,114, Pham ST58, Pinidiyapathirage MJ32, Rahman M73,123, Rakugi H102, Rolandsson O124, Ann Rozario M38, Ruggiero D65, Sala CF67, Sarju R87, Shimokawa K1, Snieder H125, Sparsø T17, Spiering W126, Starr JM29,127, Stott DJ128, Stram DO96, Sugiyama T129, Szymczak S130, Tang WHW91,131, Tong L64, Trompet S132, Turjanmaa V133,134, Ueshima H135,136, Uitterlinden AG21,43, Umemura S137, Vaarasmaki M88,89,90, van Dam RM6, van Gilst WH5, van Veldhuisen DJ5, Viikari JS138,139, Waldenberger M14,122, Wang Y37, Wang A71, Wilson R14,122, Wong TY34,74, Xiang YB85, Yamaguchi S140, Ye X37, Young RD10, Young TL141,142, Yuan JM143, Zhou X144,145,146, Asselbergs FW66,147,148, Ciullo M65, Clarke R53, Deloukas P149,150, Franke A130, Franks PW54,124,151, Franks S152, Friedlander Y153, Gross MD154, Guo Z71, Hansen T17, Jarvelin MR2,52,90,155,156, Jørgensen T98, Jukema JW132,147,157, Kähönen M133,134, Kajio H103, Kivimaki M105, Lee JY158,159, Lehtimäki T56,57, Linneberg A98,160,161, Miki T100, Pedersen O17, Samani NJ162,163, Sørensen TIA17,121,164, Takayanagi R165, Toniolo D67,166; BIOS-consortium; CARDIo GRAMplusCD; LifeLines Cohort Study; InterAct Consortium, Ahsan H64, Allayee H30,31, Chen YT47, Danesh J10,167, Deary IJ29,83, Franco OH21, Franke L20, Heijman BT168, Holbrook JD45, Isaacs A21, Kim BJ27, Lin X37, Liu J6,33, März W36,169,170, Metspalu A23, Mohlke KL46, Sanghera DK78, Shu XO79,80, van Meurs JBJ43, Vithana E34,74,141, Wickremasinghe AR32, Wijmenga C20, Wolffenbuttel BHW171, Yokota M172, Zheng W79,80, Zhu D49,50, Vineis P3, Kyrtopoulos SA173, Kleinjans JCS174, McCarthy MI12,175, Soong R38,176, Gieger C14,122, Scott J16, Teo YY#6,33,74,177,178,179, He J#8, Elliott P#3, Tai ES#6,101,180, van der Harst P#5,20,147, Kooner JS#7,16,181, Chambers JC#3,7,181.

Author information

1
Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
2
Institute of Health Sciences, University of Oulu, Oulu, Finland.
3
Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
4
Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (ASTAR), Singapore.
5
Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
6
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
7
Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK.
8
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
9
Center for Non-Communicable Diseases, Karachi, Pakistan.
10
Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
11
Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
12
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
13
Bioinformatics Support Service, Imperial College London, London, UK.
14
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
15
German Center for Diabetes Research (DZD), Neuherberg, Germany.
16
National Heart and Lung Institute, Imperial College London, London, UK.
17
Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
18
Copenhagen Prospective Studies on Asthma in Childhood (COSPAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
19
Steno Diabetes Center, Gentofte, Denmark.
20
Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
21
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
22
Vanderbilt Epidemiology Center, Center for Human Genetics Research, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
23
Estonian Genome Center, University of Tartu, Tartu, Estonia.
24
Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts, USA.
25
Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
26
Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
27
Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
28
Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine and Medical Research Council (MRC) Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.
29
Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
30
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
31
Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
32
Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
33
Genome Institute of Singapore, ASTAR, Singapore.
34
Department of Ophthalmology, National University of Singapore, Singapore.
35
Department of Paediatrics, National University of Singapore, Singapore.
36
Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
37
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
38
Cancer Science Institute of Singapore, National University of Singapore, Singapore.
39
Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.
40
Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
41
University of Ottawa Heart Institute, Cardiovascular Research Methods Centre, Ottawa, Ontario, Canada.
42
Ruddy Canadian Cardiovascular Genetics Centre, Ottawa, Ontario, Canada.
43
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
44
Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
45
Singapore Institute for Clinical Sciences (SICS), ASTAR, Singapore.
46
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
47
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
48
School of Chinese Medicine, China Medical University, Taichung, Taiwan.
49
State Key Laboratory of Medical Genetics, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
50
Shanghai Institute of Hypertension, Shanghai, China.
51
Institute of Epidemiology and Biobank popgen, Christian Albrechts University of Kiel, Kiel, Germany.
52
Department of Epidemiology and Biostatistics, MRC Health Protection Agency (PHE) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
53
Clinical Trials Support Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
54
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.
55
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
56
Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
57
Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland.
58
Vietnam National Heart Institute, Bach Mai Hospital, Hanoi, Vietnam.
59
School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
60
Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
61
Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands.
62
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
63
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
64
Department of Public Health Sciences, University of Chicago, Chicago, Illinois, USA.
65
Institute of Genetics and Biophysics A Buzzati-Traverso, CNR, Naples, Italy.
66
Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
67
Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
68
Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) 'Burlo Garofolo', Trieste, Italy.
69
University College London Genetics Institute, Department of Genetics, Environment and Evolution, University College London, London, UK.
70
Division of Genomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
71
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
72
Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina, USA.
73
UChicago Research Bangladesh, Uttara, Dhaka, Bangladesh.
74
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
75
Metabolic Disease Group, Wellcome Trust Sanger Institute, Cambridge, UK.
76
National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
77
University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
78
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
79
Vanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, USA.
80
Vanderbilt-Ingram Cancer Center, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
81
Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-National University of Singapore Graduate Medical School, Singapore.
82
Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
83
Department of Psychology, University of Edinburgh, Edinburgh, UK.
84
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
85
Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
86
Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
87
Dayanand Medical College and Hospital Unit, Hero DMC Heart Institute, Ludhiana, India.
88
Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.
89
Medical Research Center, University of Oulu, Oulu, Finland.
90
Unit of Primary Care, Oulu University Hospital, Oulu, Finland.
91
Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA.
92
Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
93
Department of Biostatistics, Vanderbilt University, Nashville, Tennessee, USA.
94
Department of Paediatrics, Yong Loo Lin School of Medicine, Singapore.
95
Human Genetics Center, University of Texas School of Public Health at Houston, Houston, Texas, USA.
96
University of Southern California Keck School of Medicine, Los Angeles, California, USA.
97
Department of Genetics, Chinese National Human Genomic Center, Shanghai, China.
98
Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.
99
Graduate School of Regional Innovation Studies, Mie University, Tsu, Japan.
100
Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
101
Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.
102
Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan.
103
National Center for Global Health and Medicine, Toyama, Japan.
104
Duke-National University of Singapore Graduate Medical School, Singapore.
105
Department of Epidemiology and Public Health, University College London, London, UK.
106
K.K. Women's and Children's Hospital, Singapore.
107
University of San Carlos Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines.
108
Department of Anthropology, Sociology and History, University of San Carlos, Cebu City, Philippines.
109
Department of Internal Medicine, Aichi-Gakuin University School of Dentistry, Nagoya, Japan.
110
Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
111
Institute of Human Genetics, Technische Universität München, Munich, Germany.
112
Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
113
Department of Medicine I, Ludwig Maximilians University Munich, Munich, Germany.
114
German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.
115
Department of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan.
116
Division of Endocrinology and Diabetes, Department of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
117
Department of Diabetes and Endocrinology, Chubu Rosai Hospital, Nagoya, Japan.
118
Heart Centre, Department of Cardiology, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland.
119
Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.
120
Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
121
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
122
Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
123
Research and Evaluation Division, Bangladesh Rehabilitation Assistance Committee (BRAC), Dhaka, Bangladesh.
124
Department of Public Health and Clinical Medicine, Section for Family Medicine, Umeå Universitet, Umeå, Sweden.
125
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
126
Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
127
Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
128
Academic Section of Geriatric Medicine, Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK.
129
Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan.
130
Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
131
Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
132
Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
133
Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
134
Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland.
135
Department of Health Science, Shiga University of Medical Science, Otsu, Japan.
136
Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan.
137
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
138
Division of Medicine, Turku University Hospital, Turku, Finland.
139
Department of Medicine, University of Turku, Turku, Finland.
140
Third Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Japan.
141
Neuroscience and Behavioural Disorders (NBD) Program, Duke-National University of Singapore Graduate Medical School, Singapore.
142
Duke Eye Center, Duke University Medical Center, Durham, North Carolina, USA.
143
Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.
144
Bioinformatics Division, Tsinghua National Laboratory for Informatics Science and Technology (TNLIST), Ministry of Education Key Laboratory of Bioinformatics, Department of Automation, Tsinghua University, Beijing, China.
145
Center for Synthetic and Systems Biology, TNLIST, Ministry of Education Key Laboratory of Bioinformatics, Department of Automation, Tsinghua University, Beijing, China.
146
Department of Psychiatry, University of Hong Kong, Hong Kong.
147
Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute of the Netherlands (ICIN)-Netherlands Heart Institute, Utrecht, the Netherlands.
148
Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK.
149
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
150
King Abdulaziz University, Jeddah, Saudi Arabia.
151
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
152
Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, UK.
153
Hebrew University, School of Public Health, Jerusalem, Israel.
154
School of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
155
Biocenter Oulu, University of Oulu, Oulu, Finland.
156
Center for Life Course Epidemiology, Faculty of Medicine, University of Oulu, Oulu, Finland.
157
ICIN, Utrecht, the Netherlands.
158
Ministry of Health and Welfare, Seoul, Republic of Korea.
159
THERAGEN ETEX Bio Institute, Suwon, Republic of Korea.
160
Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark.
161
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
162
Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK.
163
NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
164
Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
165
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan.
166
Institute of Molecular Genetics, National Research Council (CNR), Pavia, Italy.
167
Wellcome Trust Sanger Institute, Hinxton, UK.
168
Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
169
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
170
Synlab Academy, Synlab Services, Mannheim, Germany.
171
Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
172
Department of Genome Science, Aichi-Gakuin University School of Dentistry, Nagoya, Japan.
173
National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece.
174
Department of Toxicogenomics, Maastricht University, Maastricht, the Netherlands.
175
Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK.
176
Department of Pathology, National University of Singapore, Singapore.
177
National University of Singapore Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore.
178
Life Sciences Institute, National University of Singapore, Singapore.
179
Department of Statistics and Applied Probability, National University of Singapore, Singapore.
180
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
181
Imperial College Healthcare NHS Trust, London, UK.
#
Contributed equally

Abstract

We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10(-11) to 5.0 × 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10(-6)). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.

PMID:
26390057
PMCID:
PMC4719169
DOI:
10.1038/ng.3405
[Indexed for MEDLINE]
Free PMC Article

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