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J Dermatol. 2015 Dec;42(12):1137-42. doi: 10.1111/1346-8138.13072. Epub 2015 Sep 21.

Microbiome and pediatric atopic dermatitis.

Author information

1
Duke University School of Medicine, Durham, North Carolina, USA.
2
Department of Dermatology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA.
3
Clinical Microbiology-Immunology Laboratories, University of North Carolina Hospitals, Chapel Hill, North Carolina, USA.

Abstract

Atopic dermatitis is a chronic inflammatory skin condition with drastic impacts on pediatric health. The pathogenesis of this common disease is not well understood, and the complex role of the skin microbiome in the pathogenesis and progression of atopic dermatitis is being elucidated. Skin commensal organisms promote normal immune system functions and prevent the colonization of pathogens. Alterations in the skin microbiome may lead to increased Staphylococcus aureus colonization and atopic dermatitis progression. Despite the evidence for their important role, probiotics have not been deemed efficacious for the treatment of atopic dermatitis, although studies suggest that probiotics may be effective at preventing the development of atopic dermatitis when given to young infants. This review will cover the most recent published work on the microbiome and pediatric atopic dermatitis.

KEYWORDS:

Staphylococcus aureus; antimicrobial cationic peptides; atopic dermatitis; microbiota; probiotics

PMID:
26388516
DOI:
10.1111/1346-8138.13072
[Indexed for MEDLINE]

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