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Ocul Surf. 2016 Jan;14(1):56-63. doi: 10.1016/j.jtos.2015.07.003. Epub 2015 Sep 24.

Accelerated Restoration of Ocular Surface Health in Dry Eye Disease by Self-Retained Cryopreserved Amniotic Membrane.

Author information

1
Ocular Surface Center and Tissuetech Inc., Miami FL, USA.
2
Department of Ophthalmology, Yan'An Hospital of Kunming City, Kunming, Yunnan, China.
3
Department of Ophthalmology, Shenzhen Children's Hospital, Shenzhen, Guangzhou, China.
4
Florida International University Herbert Wertheim College of Medicine, Miami, FL, USA.
5
Ocular Surface Center and Tissuetech Inc., Miami FL, USA. Electronic address: stseng@ocularsurface.com.

Abstract

PURPOSE:

To evaluate the clinical efficacy of self-retained cryopreserved amniotic membrane in treating dry eye disease.

METHODS:

Retrospective review of 10 patients treated with self-retained cryopreserved amniotic membrane (PROKERA® Slim [PKS], Bio-Tissue, Miami, FL) for moderate-to-severe dry eye refractory to conventional maximal medical treatments. Patients' symptoms, use of medications, conjunctival inflammation, corneal staining, and visual acuity were compared before and after treatment.

RESULTS:

PKS was placed in 15 eyes of the 10 patients for 4.9 ± 1.5 days. All patients experienced symptomatic relief for a period of 4.2 ± 4.7 months (P<.001). Such improvement was accompanied by reduction of OSDI scores (P<.001), use of topical medications (P<.001), conjunctival hyperemia (P<.001), corneal staining (P<.001), and improvement of the visual acuity (P=.06). Linear regression analysis estimated that the optimal duration of PKS placement was 5 days to achieve an average symptom-free duration of 4 months in patients with dry eye. Surprisingly, PKS placement also generated improvement in the contralateral eyes.

CONCLUSION:

This pilot study suggests that self-retained cryopreserved amniotic membrane via PKS can be used to treat moderate dry eye diseases and warrants further prospective controlled studies.

KEYWORDS:

PROKERA®; amniotic membrane; dry eye; keratitis; ocular surface

PMID:
26387870
PMCID:
PMC4706470
DOI:
10.1016/j.jtos.2015.07.003
[Indexed for MEDLINE]
Free PMC Article

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