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Neuromodulation. 2016 Jan;19(1):20-24. doi: 10.1111/ner.12348. Epub 2015 Sep 21.

Deep Brain Recordings Using an Implanted Pulse Generator in Parkinson's Disease.

Author information

1
Department of Neurology, Campus Virchow Klinikum, Charité - University Medicine Berlin, Berlin, Germany.
2
Department of Neurology, Vivantes Hospital Berlin Spandau, Berlin, Germany.
3
Department of Neurosurgery, Campus Virchow Klinikum, Charité - University Medicine Berlin, Berlin, Germany.
4
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
5
Medical Research Council Brain Network Dynamics Unit at the University of Oxford, Oxford, United Kingdom.
6
Berlin School of Mind and Brain, Charité - University Medicine Berlin, Berlin, Germany.
7
NeuroCure, Charité - University Medicine Berlin, Berlin, Germany.
#
Contributed equally

Abstract

OBJECTIVES:

Recent studies suggest that oscillatory beta activity could be used as a state biomarker in patients with Parkinson's disease for subthalamic closed-loop stimulation with the intention of improving clinical benefit. Here we investigate the feasibility of subthalamic recordings via a novel chronically implanted pulse generator.

METHODS:

Subthalamic local field potential recordings were obtained from eight patients before and during deep brain stimulation (DBS). All data were analyzed in the frequency domain using Fourier transform-based methods and compared between ON and OFF stimulation conditions.

RESULTS:

Distinct peaks of oscillatory beta band activity were found in 12 of 15 electrodes. DBS induced a significant frequency specific suppression of oscillatory beta activity (p = 0.002).

CONCLUSION:

The results of the study suggest that oscillatory beta band synchronization and its modulation by DBS is recordable with a system suitable for chronic implantation and may serve as a biomarker for subthalamic closed-loop stimulation in patients with Parkinson's disease.

KEYWORDS:

Basal ganglia; beta oscillations; deep brain stimulation; local field potentials; subthalamic nucleus

PMID:
26387795
PMCID:
PMC4881811
DOI:
10.1111/ner.12348
[Indexed for MEDLINE]
Free PMC Article

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