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Regen Med. 2016 Jan;11(1):33-43. doi: 10.2217/rme.15.69. Epub 2015 Sep 21.

Treatment of perianal fistulas with human embryonic stem cell-derived mesenchymal stem cells: a canine model of human fistulizing Crohn's disease.

Author information

1
Department of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA 01536, USA.
2
Ocata Therapeutics, 33 Locke Drive, Marlborough, MA 01752, USA.

Abstract

AIM:

To evaluate the safety and efficacy of intralesional injection of human embryonic stem cell (hESC)-derived mesenchymal stem/stromal cells (MSCs) in canine anal furunculosis dogs.

MATERIALS & METHODS:

Dogs naturally develop an immune-mediated disease called canine anal furunculosis, which shares many features with human fistulizing Crohn's disease.

RESULTS:

The hESC-MSCs were well tolerated and 1 month postinjection, accompanied by reduced serum levels of IL-2 and IL-6, two inflammatory cytokines associated with Crohn's disease. All six dogs were found to be completely free of fistulas at 3 months postinjection. However, at 6 months, two dogs had some fistula relapse.

CONCLUSION:

Results of this study provide the first evidence of the safety and therapeutic potential of hESC-MSCs in a large animal model.

KEYWORDS:

Crohn's disease; canine perianal furunculosis; human embryonic stem cells; mesenchymal stem cells; perianal fistulas; pluripotent stem cells

PMID:
26387424
DOI:
10.2217/rme.15.69
[Indexed for MEDLINE]
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