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J Am Acad Dermatol. 2015 Nov;73(5):856-63. doi: 10.1016/j.jaad.2015.08.015. Epub 2015 Sep 18.

Role of sebaceous glands in inflammatory dermatoses.

Author information

1
Department of Dermatology, University of California, Davis, California.
2
School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
3
School of Medicine, University of California, Davis, California.
4
David Geffen School of Medicine, University of California, Los Angeles, California.
5
Department of Dermatology, University of California, San Francisco, California.
6
Department of Dermatology, University of California, Davis, California. Electronic address: rksivamani@ucdavis.edu.

Abstract

Skin is an important interface between the host and its environment. Inflammatory dermatoses often have disrupted skin barrier function, rendering patients more susceptible to allergenic triggers leading to an exaggerated immune response. The skin surface lipid film, an important component of the skin barrier, comprises a mixture of keratinocyte and sebaceous gland-derived lipids. Recent evidence demonstrated that defective keratinocyte lipid synthesis predisposes for the development of atopic dermatitis. However, the important role of sebaceous gland-derived lipids in skin inflammatory diseases may be underrecognized. This overview focuses on the importance of the contribution of sebaceous glands to barrier function. Sebaceous gland alteration may play a role in the pathogenesis of common skin diseases including acne vulgaris, atopic dermatitis, psoriasis, rosacea, and seborrheic dermatitis.

KEYWORDS:

acne; atopic dermatitis; eczema; psoriasis; rosacea; sebocytes; seborrheic dermatitis; sebum

PMID:
26386632
DOI:
10.1016/j.jaad.2015.08.015
[Indexed for MEDLINE]

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