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Biochimie. 2016 Mar;122:324-38. doi: 10.1016/j.biochi.2015.09.018. Epub 2015 Sep 16.

The Paracaspase MALT1.

Author information

1
Program in Cell Death and Survival Networks, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA; Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
2
Program in Cell Death and Survival Networks, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: gsalvesen@sbpdiscovery.org.

Abstract

The human paracaspase MALT1 is a caspase homolog that plays a central role in NF-κB signaling. Over the past few years it has become clear that this is due to a combination of its scaffolding and proteolytic function. Knockout mice and mice expressing a catalytically dead variant of the protease have provided valuable information. This review aims to provide an overview of recent developments regarding the enzymatic mechanism and specificity of MALT1, its substrates discovered to date, different mouse models, as well as the role of MALT1 in NF-κB signaling downstream of a variety of different receptors.

KEYWORDS:

Caspase; Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1); NF-κB signaling; Protease

PMID:
26386283
PMCID:
PMC4747852
[Available on 2017-03-01]
DOI:
10.1016/j.biochi.2015.09.018
[Indexed for MEDLINE]
Free PMC Article

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