Format

Send to

Choose Destination
Hepatol Res. 2016 May;46(6):565-74. doi: 10.1111/hepr.12592. Epub 2015 Oct 8.

Outcomes of laparoscopic hepatic resection versus percutaneous radiofrequency ablation for hepatocellular carcinoma located at the liver surface: A case-control study with propensity score matching.

Author information

1
Departments of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
2
Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Abstract

AIM:

Percutaneous radiofrequency ablation (P-RFA) therapy is a widely applied treatment for small hepatocellular carcinoma (HCC); however, local recurrence is a major issue of HCC located at the surface of the liver (surface HCC). The aim of this study was to compare the outcome of laparoscopic hepatic resection (LH) and P-RFA for surface HCC in case-control patient groups using the propensity score.

METHODS:

Between 2011 and 2013, 40 and 52 patients underwent LH and P-RFA for surface HCC (≤3 cm, 1-3 nodules). To correct the difference in clinicopathological factors between the two groups, propensity score matching was used at a 1:1 ratio, which resulted in a comparison of 27 patients/group. We compared outcomes between the two groups, with special reference to local recurrence.

RESULTS:

Clinicopathological variables were well balanced between the two groups. One patient in the LH group was converted to open surgery due to adhesion. The incidence of complications was 0% in the P-RFA group and 15% (four patients) in the LH group (P = 0.11); however, none of these four patients in the LH group sustained severe complications. The duration of hospitalization following treatment was longer in the LH group than in the P-RFA group (12.6 vs 7.6 days, P < 0.01). The incidence of local recurrence was lower in the LH group (0%) than in the P-RFA group (eight patients [30%], P = 0.004).

CONCLUSION:

LH is an effective treatment for surface HCC with regard to control of local recurrence.

KEYWORDS:

hepatocellular carcinoma; laparoscopic hepatic resection; local recurrence; location at liver surface; radiofrequency ablation

PMID:
26386248
DOI:
10.1111/hepr.12592

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center