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Biochim Biophys Acta. 2016 May;1863(5):1061-9. doi: 10.1016/j.bbamcr.2015.09.016. Epub 2015 Sep 16.

No peroxisome is an island - Peroxisome contact sites.

Author information

1
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
2
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: einat.zalckvar@weizmann.ac.il.

Abstract

In order to optimize their multiple cellular functions, peroxisomes must collaborate and communicate with the surrounding organelles. A common way of communication between organelles is through physical membrane contact sites where membranes of two organelles are tethered, facilitating exchange of small molecules and intracellular signaling. In addition contact sites are important for controlling processes such as metabolism, organelle trafficking, inheritance and division. How peroxisomes rely on contact sites for their various cellular activities is only recently starting to be appreciated and explored and the extent of peroxisomal communication, their contact sites and their functions are less characterized. In this review we summarize the identified peroxisomal contact sites, their tethering complexes and their potential physiological roles. Additionally, we highlight some of the preliminary evidence that exists in the field for unexplored peroxisomal contact sites.

KEYWORDS:

Chloroplast; Endoplasmic reticulum; Lipid droplet; Membrane contact site; Mitochondria; Peroxisome

PMID:
26384874
PMCID:
PMC4869879
DOI:
10.1016/j.bbamcr.2015.09.016
[Indexed for MEDLINE]
Free PMC Article

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