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Immunity. 2015 Oct 20;43(4):776-87. doi: 10.1016/j.immuni.2015.08.015. Epub 2015 Sep 15.

Perforin-Positive Dendritic Cells Exhibit an Immuno-regulatory Role in Metabolic Syndrome and Autoimmunity.

Author information

1
Department of Immunology, Weizmann Institute of Science, Herzel St 1, Rehovot 76100, Israel.
2
Department of Immunology, Weizmann Institute of Science, Herzel St 1, Rehovot 76100, Israel. Electronic address: yair.reisner@weizmann.ac.il.

Abstract

Emerging evidence suggests that immunological mechanisms underlie metabolic control of adipose tissue. Here, we have shown the regulatory impact of a rare subpopulation of dendritic cells, rich in perforin-containing granules (perf-DCs). Using bone marrow transplantation to generate animals selectively lacking perf-DCs, we found that these chimeras progressively gained weight and exhibited features of metabolic syndrome. This phenotype was associated with an altered repertoire of T cells residing in adipose tissue and could be completely prevented by T cell depletion in vivo. A similar impact of perf-DCs on inflammatory T cells was also found in a well-defined model of multiple sclerosis, experimental autoimmune encephlalomyelitis (EAE). Thus, perf-DCs probably represent a regulatory cell subpopulation critical for protection from metabolic syndrome and autoimmunity.

PMID:
26384546
DOI:
10.1016/j.immuni.2015.08.015
[Indexed for MEDLINE]
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