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Taiwan J Obstet Gynecol. 2015 Aug;54(4):350-4. doi: 10.1016/j.tjog.2013.10.045.

Maternal serum copeptin concentrations in early- and late-onset pre-eclampsia.

Author information

1
Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey. Electronic address: drabdtuten@gmail.com.
2
Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.
3
Department of Medical Biochemistry, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.
4
Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.

Abstract

OBJECTIVE:

Early-onset pre-eclampsia is primarily associated with placental dysfunction, whereas late-onset pre-eclampsia is defined as a maternal constitutional disorder. As a protein cosynthesized with vasopressin, copeptin is a potential marker of metabolic syndrome and insulin resistance, which shares similar risk factors with pre-eclampsia. The aim of this study was to investigate the copeptin levels in patients with early-onset and late-onset pre-eclampsia.

MATERIALS AND METHODS:

A total of 80 pregnant women receiving antenatal and obstetric care were recruited. The patients were subdivided into four groups: Early-onset pre-eclampsia (n = 20), late-onset pre-eclampsia (n = 20), and two control groups of similar gestational ages for both pre-eclamptic groups (n = 20 in each group). The maternal serum copeptin levels were measured using an enzyme-linked immunosorbent assay.

RESULTS:

The mean copeptin levels were 0.92 ± 0.57 ng/mL and 1.65 ± 0.95 ng/mL in the early-onset and late-onset pre-eclampsia groups, respectively. These values were higher compared with the control groups (0.54 ± 0.25 ng/mL and 1.15 ± 0.94 ng/mL, respectively). However, the difference was only statistically significant in the early-onset pre-eclampsia group (p = 0.011). Copeptin levels were associated only with gestational age and systolic-diastolic blood pressure.

CONCLUSION:

Our results suggest that copeptin levels might be useful in the evaluation of the severity of pre-eclampsia. However, copeptin might be involved in early- rather than late-onset pre-eclampsia.

KEYWORDS:

copeptin; early-onset pre-eclampsia; gestational age; late-onset pre-eclampsia; pre-eclampsia

PMID:
26384049
DOI:
10.1016/j.tjog.2013.10.045
[Indexed for MEDLINE]
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