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Metabolism. 2015 Nov;64(11):1521-9. doi: 10.1016/j.metabol.2015.07.021. Epub 2015 Jul 30.

Effects of pistachios on the lipid/lipoprotein profile, glycemic control, inflammation, and endothelial function in type 2 diabetes: A randomized trial.

Author information

1
Department of Biobehavioral Health, 219 Biobehavioral Health Building, The Pennsylvania State University, University Park, PA, 16802, USA.
2
Department of Nutritional Sciences, 110 Chandlee Laboratory, The Pennsylvania State University, University Park, PA, 16802, USA.
3
Department of Biobehavioral Health, 219 Biobehavioral Health Building, The Pennsylvania State University, University Park, PA, 16802, USA; Department of Nutritional Sciences, 110 Chandlee Laboratory, The Pennsylvania State University, University Park, PA, 16802, USA. Electronic address: sgw2@psu.edu.

Abstract

OBJECTIVE:

The health benefits of regular nut consumption have been well-documented; however, effects on cardiovascular risk in diabetes are emerging. This study examined the effects of daily pistachio consumption on the lipid/lipoprotein profile, glycemic control, markers of inflammation, and endothelial function in adults with type 2 diabetes.

MATERIALS/METHODS:

We enrolled 30 adults (40-74 years) with well-controlled type 2 diabetes (mean glycated hemoglobin 6.2%) in a randomized, crossover, controlled feeding study. After a 2-week run-in period, participants consumed nutritionally-adequate diets with pistachios (contributing 20% of total energy) or without pistachios for 4 weeks each, separated by a 2-week washout. We assessed fasting lipids/lipoproteins, glycemic measures (while fasted and during a 75 g oral glucose tolerance test), inflammatory markers, and endothelial function after each diet period.

RESULTS:

Total cholesterol and the ratio of total to HDL cholesterol were significantly lower (p<0.05) following the pistachio diet (4.00 mmol/L and 4.06 mmol/L, respectively) compared to the control diet (4.15 mmol/L and 4.37 mmol/L, respectively). Triglycerides were significantly lower (p=0.003) following the pistachio diet (1.56 mmol/L) compared to the control diet (1.84 mmol/L). There were no treatment differences in fasting glucose and insulin, but fructosamine was significantly lower (p=0.03) following the pistachio diet (228.5 μmol/l) compared to the control diet (233.5 μmol/l). Inflammatory markers and endothelial function were unchanged.

CONCLUSION:

Daily pistachio consumption can improve some cardiometabolic risk factors in adults with well-controlled type 2 diabetes. Our findings support recommendations that individuals with diabetes follow healthy dietary patterns that include nuts.

KEYWORDS:

Cholesterol; Endothelial function; Glycemia; Nuts; Pistachios

PMID:
26383493
PMCID:
PMC4872503
DOI:
10.1016/j.metabol.2015.07.021
[Indexed for MEDLINE]
Free PMC Article

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