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Nat Immunol. 2015 Oct;16(10):1014-24. doi: 10.1038/ni.3273.

Autophagy and autophagy-related proteins in the immune system.

Author information

1
Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan.
2
Department of Genetics, Graduate School of Medicine, Osaka University, Osaka, Japan.
3
Division of Molecular Genetics, Institute for Enzyme Research, Tokushima University, Tokushima, Japan.
4
Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.

Abstract

Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In addition, studies have revealed other roles for the autophagic machinery beyond autophagy. In this Review, we introduce advances in the knowledge of the roles of autophagy and its components in immunity, including innate immunity, inflammatory responses and adaptive immunity.

PMID:
26382870
DOI:
10.1038/ni.3273
[Indexed for MEDLINE]

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