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Br J Nutr. 2015 Nov 28;114(10):1647-55. doi: 10.1017/S0007114515003372. Epub 2015 Sep 18.

Vitamin D status is associated with cardiometabolic markers in 8-11-year-old children, independently of body fat and physical activity.

Author information

1
1Department of Nutrition,Exercise and Sports, Faculty of Science,University of Copenhagen,Denmark,Rolighedsvej 26,1958 Frederiksberg C,Denmark.
2
3Division of Nutrition,The National Food Institute,Technical University of Denmark,Mørkhøj Bygade 19,2860 Søborg,Denmark.
3
4Department of Clinical Biochemistry,Section of Molecular Diagnostics,Aalborg University Hospital,Hobrovej 18-22,9000 Aalborg,Denmark.

Abstract

Vitamin D status has been associated with cardiometabolic markers even in children, but the associations may be confounded by fat mass and physical activity behaviour. This study investigated associations between vitamin D status and cardiometabolic risk profile, as well as the impact of fat mass and physical activity in Danish 8-11-year-old children, using baseline data from 782 children participating in the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study. We assessed vitamin D status as serum 25-hydroxyvitamin D (25(OH)D) and measured blood pressure, fasting plasma glucose, homoeostasis model of assessment-insulin resistance, plasma lipids, inflammatory markers, anthropometry and fat mass by dual-energy X-ray absorptiometry, and physical activity by 7 d accelerometry during August-November. Mean serum 25(OH)D was 60·8 (sd 18·7) nmol/l. Each 10 mmol/l 25(OH)D increase was associated with lower diastolic blood pressure (-0·3 mmHg, 95 % CI -0·6, -0·0) (P=0·02), total cholesterol (-0·07 mmol/l, 95 % CI -0·10, -0·05), LDL-cholesterol (-0·05 mmol/l, 95 % CI -0·08, -0·03), TAG (-0·02 mmol/l, 95 % CI -0·03, -0·01) (P≤0·001 for all lipids) and lower metabolic syndrome (MetS) score (P=0·01). Adjustment for fat mass index did not change the associations, but the association with blood pressure became borderline significant after adjustment for physical activity (P=0·06). In conclusion, vitamin D status was negatively associated with blood pressure, plasma lipids and a MetS score in Danish school children with low prevalence of vitamin D deficiency, and apart from blood pressure the associations were independent of body fat and physical activity. The potential underlying cause-effect relationship and possible long-term implications should be investigated in randomised controlled trials.

KEYWORDS:

25(OH)D 25-hydroxyvitamin D; Cardiometabolic health; Children; FMI fat mass index; HOMA-IR homoeostasis model of assessment of insulin resistance; MVPA moderate-to-vigorous physical activity; MetS metabolic syndrome; PTH parathyroid hormone; Vitamin D

PMID:
26382732
DOI:
10.1017/S0007114515003372
[Indexed for MEDLINE]

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