Synthesis of E-Alkyl Alkenes from Terminal Alkynes via Ni-Catalyzed Cross-Coupling of Alkyl Halides with B-Alkenyl-9-borabicyclo[3.3.1]nonanes

Org Lett. 2015 Oct 2;17(19):4910-3. doi: 10.1021/acs.orglett.5b02482.

Abstract

The first Ni-catalyzed Suzuki-Miyaura coupling of alkyl halides with alkenyl-(9-BBN) reagents is reported. Both primary and secondary alkyl halides including alkyl chlorides can be coupled. The coupling method can be combined with hydroboration of terminal alkynes, allowing the expedited synthesis of functionalized alkyl alkenes from readily available alkynes with complete (E)-selectivity in one pot. The method was applied to the total synthesis of (±)-Recifeiolide, a natural macrolide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkanes / chemistry*
  • Alkenes / chemical synthesis*
  • Alkenes / chemistry
  • Alkynes / chemistry*
  • Catalysis
  • Cross-Linking Reagents / chemistry*
  • Hydrocarbons, Chlorinated / chemical synthesis*
  • Hydrocarbons, Chlorinated / chemistry
  • Lactones / chemical synthesis*
  • Lactones / chemistry
  • Molecular Structure
  • Nickel / chemistry*
  • Stereoisomerism

Substances

  • Alkanes
  • Alkenes
  • Alkynes
  • Cross-Linking Reagents
  • Hydrocarbons, Chlorinated
  • Lactones
  • recifeiolide
  • Nickel
  • nonane