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J Matern Fetal Neonatal Med. 2016;29(14):2312-5. doi: 10.3109/14767058.2015.1085013. Epub 2015 Sep 18.

Does preeclampsia have any adverse effect on fetal heart?

Author information

1
a Department of Gynecology and Obstetrics , Acibadem Bodrum Hospital , Mugla , Turkey .
2
b Faculty of Medicine, Department of Gynecology and Obstetrics , Yeditepe University , Istanbul , Turkey .
3
c Department of Gynecology and Obstetrics , Kanuni Sultan Suleyman Education and Research Hospital , Istanbul , Turkey .
4
d Department of Gynecology and Obstetrics , Cekerek State Hospital , Yozgat , Turkey .
5
e Department of Biochemistry , Luleburgaz State Hospital , Kirklareli , Turkey .
6
f Department of Biochemistry , Kartal Dr Lutfi Kirdar Education and Research Hospital , Istanbul , Turkey , and.
7
g Faculty of Medicine, Department of Gynecology and Obstetrics , Sakarya University , Sakarya , Turkey.

Abstract

OBJECTIVE:

To determine whether preeclampsia causes fetal cardiac cell damage by assessing umbilical artery NT-proBNP, cardiac troponin I and homocysteine.

METHODS:

A cross-sectional study with 73 fetuses between 26 and 40 weeks of gestation was performed. Thirty-three healthy mothers' fetuses were control group (Group I). While 12 mildly pre-eclamptic mothers' fetuses constituted Group II, 28 fetuses of severe pre-eclamptic mothers were Group III.

RESULTS:

Umbilical cord mean NT-proBNP levels of Group I, II and III are 520.8 ± 404.5 pg/ml; 664.2 ± 215.9 pg/ml; and 1932.8 ± 2979.5 pg/ml, respectively (p = 0.0001). The number of neonates with NT-proBNP > 500 pg/mL that indicates severe cardiac damage is higher in Group III (p = 0.001). The mean homocysteine levels are also statistically significantly higher in Group III. Cardiac troponin I levels are not different between the groups (p = 0.46).

CONCLUSION:

Increased NT-proBNP and homocysteine might not only indicate some degree of in-utero cardiac cell damage but also feto-placental endothelial injury in the fetuses of severe pre-eclamptic mothers. Our finding that shows no evidence of correlation between cardiac troponin I levels with cell damage and endothelial injury requires further research.

KEYWORDS:

Blood marker; NT-proBNP; cardiac cell injury; fetal; fetal heart; homocysteine; neonatal; preeclampsia

PMID:
26381715
DOI:
10.3109/14767058.2015.1085013
[Indexed for MEDLINE]

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